Description:
(+)-JQ-1 is a potent and selective BET bromodomain inhibitor, IC50 values are 77 nM and 33 nM for inhibiting BRD4 (N-terminal) and BRD4 (C-terminal), respectively.
- Molecular Weight: 456.99
- Molecular Formula: C₂₃H₂₅ClN₄O₂S
Canonical SMILES:
O=C(OC(C)(C)C)C[C@@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChIKey: DNVXATUJJDPFDM-KRWDZBQOSA-N- Solubility: In DMSO: ≥ 45 mg/mL (98.47 mM)* ''≥ means soluble, but saturation unknown.
- Appearance: White solid
- Storage: Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
Synonyms:
JQ1
More details are to be found on supplier website
