BGC > Product Search > Tivozanib | 475108-18-0

Molecular Formula: C22H19ClN4O5
Molecular Weight: 454.86

Molecular Formula: C22H19ClN4O5
Molecular Weight: 454.86

Molecular Formula: C22H19ClN4O5
Molecular Weight: 454.86

Molecular Formula: C22H19ClN4O5
Molecular Weight: 454.86

Description :
Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. Check for active clinical trials or closed clinical trials using this agent.

• Molecular Weight :454.86306
• Purity :0.98

Molecular Formula :
C22H19ClN4O5
Canonical SMILES :
CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
InChI :
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChIKey :
SPMVMDHWKHCIDT-UHFFFAOYSA-N
Appearance :
Solid powder
Synonyms :
AV-951; AV951; AV 951; KRN951; KRN 951; KRN-951,

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