BGC > Product Search > ALK5 Inhibitor II | 446859-33-2

Molecular Formula: C17H13N5
Molecular Weight: 287.31862
Hazard Symbols: T
UN Number: UN 2811
WGKGermany: 3

Molecular Formula: C17H13N5
Molecular Weight: 287.31862
Hazard Symbols: T
UN Number: UN 2811
WGKGermany: 3

Molecular Formula: C17H13N5
Molecular Weight: 287.31862
Hazard Symbols: T
UN Number: UN 2811
WGKGermany: 3

Molecular Formula: C17H13N5
Molecular Weight: 287.31862
Hazard Symbols: T
UN Number: UN 2811
WGKGermany: 3

Description :
ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form.

• Molecular Weight :323.8
• Purity :≥98%

Molecular Formula :
C17H13N5·HCl
Canonical SMILES :
CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1
InChI :
InChI=1S/C17H13N5.ClH/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14;/h2-10H,1H3,(H,19,22);1H
InChIKey :
ZKLHJSQURWMEIX-UHFFFAOYSA-N
Solubility :
Soluble to 28.73 mg/mL in DMSO, to 5.75 mg/mL in ethanol.
Appearance :
Crystalline Solid
Synonyms :
E 616452; RepSox; SJN 2511

More details are to be found here

Description :
ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form.

• Molecular Weight :323.8
• Purity :≥98%

Molecular Formula :
C17H13N5·HCl
Canonical SMILES :
CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1
InChI :
InChI=1S/C17H13N5.ClH/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14;/h2-10H,1H3,(H,19,22);1H
InChIKey :
ZKLHJSQURWMEIX-UHFFFAOYSA-N
Solubility :
Soluble to 28.73 mg/mL in DMSO, to 5.75 mg/mL in ethanol.
Appearance :
Crystalline Solid
Synonyms :
E 616452; RepSox; SJN 2511

More details are to be found here