BGC > Product Search > Onalespib | 912999-49-6

Molecular Formula: C24H31N3O3
Molecular Weight: 409.52124

Molecular Formula: C24H31N3O3
Molecular Weight: 409.52124

Description :
Onalespib, also known as AT13387, is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

• Molecular Weight :409.52
• Purity :> 98%

Molecular Formula :
C24H31N3O3
Canonical SMILES :
CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
InChI :
InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChIKey :
IFRGXKKQHBVPCQ-UHFFFAOYSA-N
Solubility :
DMSO:≥ 40 mg/mL
Appearance :
White solid powder
Storage : 3 years -20°C powder, 6 months -80°C in solvent.
Synonyms :
AT13387; AT 13387; AT-13387

More details are to be found here

Description :
Onalespib, also known as AT13387, is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

• Molecular Weight :409.52
• Purity :> 98%

Molecular Formula :
C24H31N3O3
Canonical SMILES :
CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
InChI :
InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChIKey :
IFRGXKKQHBVPCQ-UHFFFAOYSA-N
Solubility :
DMSO:≥ 40 mg/mL
Appearance :
White solid powder
Storage : 3 years -20°C powder, 6 months -80°C in solvent.
Synonyms :
AT13387; AT 13387; AT-13387

More details are to be found here